Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Telbivudine
Drug ID BADD_D02145
Description Telbivudine is a synthetic thymidine nucleoside analog with specific activity against the hepatitis B virus. Telbivudine is orally administered, with good tolerance, lack of toxicity and no dose-limiting side effects.
Indications and Usage For the treatment of chronic hepatitis B in adult and adolescent patients ≥16 years of age with evidence of viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.
Marketing Status approved; investigational
ATC Code J05AF11
DrugBank ID DB01265
KEGG ID D06675
MeSH ID D000077712
PubChem ID 159269
TTD Drug ID D0CL9S
NDC Product Code Not Available
UNII 2OC4HKD3SF
Synonyms Telbivudine | 1-(2-Deoxy-beta-L-erythropentafuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione | beta-L-2'-Deoxythymidine | beta L 2' Deoxythymidine | Telbivudin | Tyzeka
Chemical Information
Molecular Formula C10H14N2O5
CAS Registry Number 3424-98-4
SMILES CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pneumonia streptococcal22.07.06.006; 11.02.06.005--Not Available
Productive cough22.02.03.005--
Pruritus23.03.12.001--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Renal failure20.01.03.005--Not Available
Rhabdomyolysis15.05.05.002--
Rhinorrhoea22.12.03.021--
Sciatica17.10.03.001; 15.10.01.001--Not Available
Sepsis11.01.11.003--
Sinus headache22.12.03.022; 17.14.01.002--
Skin disorder23.03.03.007--Not Available
Tenderness08.01.08.005--Not Available
Tension headache17.14.01.004; 19.24.01.009--Not Available
Thrombocytopenia01.08.01.002--Not Available
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Vomiting07.01.07.003--
Fibromyalgia15.05.02.002--Not Available
Myofascial pain syndrome15.05.02.003--Not Available
Musculoskeletal chest pain22.09.01.001; 15.03.04.012--
Musculoskeletal stiffness15.03.05.027--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Connective tissue disorder10.04.04.026; 15.06.01.006--Not Available
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Ill-defined disorder08.01.03.049--Not Available
Disease progression08.01.03.038--
Hepatobiliary disease09.01.08.003--Not Available
Renal impairment20.01.03.010--Not Available
Non-cardiac chest pain22.12.02.009; 08.01.08.006--
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