Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Timolol
Drug ID BADD_D02219
Description Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes.[L6724] It is also used in tablet form as a drug to treat hypertension.[L6727] Timolol was first approved by the FDA in 1978.[L6724] This drug is marketed by several manufacturers [L6736] and is an effective agent for the management of conditions such as open-angle glaucoma and hypertension.
Indications and Usage Ophthalmic timolol is indicated for the treatment of increased intraocular pressure in patients with ocular hypertension or open-angle glaucoma. The oral form of this drug is used to treat high blood pressure.[L6724,L6727] In certain cases, timolol is used in the prevention of migraine headaches.[A179530,L6742]
Marketing Status approved
ATC Code C07AA06; S01ED01
DrugBank ID DB00373
KEGG ID D00378; D08600
MeSH ID D013999
PubChem ID 33624
TTD Drug ID D05UVD
NDC Product Code 82584-001; 82584-002; 76478-001; 17478-189; 76478-002
UNII 817W3C6175
Synonyms Timolol | Timolol Maleate | Timolol Maleate, (1:1) Salt | (S)-1-((1,1-Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadazol-3-yl)oxy)-2-propanol | 2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, (S)- | Timoptic | Timoptol | Timacar | Timolol Hemihydrate | Blocadren | L-714,465 | L 714,465 | L714,465 | MK-950 | MK 950 | MK950 | Optimol
Chemical Information
Molecular Formula C13H24N4O3S
CAS Registry Number 26839-75-8
SMILES CC(C)(C)NCC(COC1=NSN=C1N2CCOCC2)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dry eye06.08.02.001--
Dry mouth07.06.01.002--
Dupuytren's contracture15.03.05.0100.000150%Not Available
Dysgeusia17.02.07.003; 07.14.03.0010.000341%
Dyspepsia07.01.02.001--
Dyspnoea02.11.05.003; 22.02.01.0040.000341%
Dysuria20.02.02.002--
Ear infection11.01.05.001; 04.03.01.006--Not Available
Erythema23.03.06.0010.000391%Not Available
Erythema of eyelid23.03.06.006; 06.04.04.003--Not Available
Eye discharge06.04.05.0010.000341%Not Available
Eye disorder06.08.03.001--Not Available
Eye inflammation06.04.05.0020.000341%Not Available
Eye irritation06.04.05.0030.003461%Not Available
Eye pain06.08.03.0020.001294%
Eye swelling06.08.03.0030.000512%Not Available
Eyelid ptosis17.17.02.004; 06.05.01.002--Not Available
Fatigue08.01.01.0020.000341%
Feeling abnormal08.01.09.014--Not Available
Fibrosis08.03.01.001--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Glaucoma06.03.01.0020.000150%
Hallucination19.10.04.003--
Hallucination, visual19.10.04.007--Not Available
Headache17.14.01.001--
Hepatomegaly09.01.05.001--Not Available
Hyperaemia24.03.02.002--Not Available
Hyperglycaemia05.06.02.002; 14.06.02.0020.000100%
Hyperhidrosis23.02.03.004; 08.01.03.028--
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ADReCS-Target
Drug Name ADR Term Target
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