Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Valganciclovir hydrochloride
Drug ID BADD_D02327
Description Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases.
Indications and Usage Valganciclovir is an antiviral medication used for the treatment of cytomegalovirus infections.
Marketing Status approved; investigational
ATC Code J05AB14
DrugBank ID DB01610
KEGG ID D03256
MeSH ID D000077562
PubChem ID 135413534
TTD Drug ID D06GWF
NDC Product Code 12869-038; 55111-884; 63739-357; 0603-6330; 55111-929; 61876-0072; 27241-159; 64380-153; 17337-0040; 63310-2410; 65015-798; 65977-0070; 65015-818; 31722-837; 43598-356; 61269-485; 72205-019; 69875-8044; 0591-2579; 65862-756; 0004-0039; 63629-2288; 65862-753; 63285-852; 71666-008
UNII 4P3T9QF9NZ
Synonyms Valganciclovir | Ganciclovir L-valyl Ester | Ganciclovir L valyl Ester | Valcyt | Valganciclovir Hydrochloride | Valcyte
Chemical Information
Molecular Formula C14H23ClN6O5
CAS Registry Number 175865-59-5
SMILES CC(C)C(C(=O)OCC(CO)OCN1C=NC2=C1N=C(NC2=O)N)N.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypertension24.08.02.001--
Hypocalcaemia14.04.01.004--
Hypokalaemia14.05.03.002--
Hypomagnesaemia14.04.02.001--
Hypophosphataemia14.04.03.001--
Hypotension24.06.03.002--
Infection11.01.08.002--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Muscle spasms15.05.03.004--
Nausea07.01.07.001--
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.004--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral08.01.07.007; 14.05.06.011; 02.05.04.007--
Pain08.01.08.004--
Pancytopenia01.03.03.003--Not Available
Paraesthesia23.03.03.094; 17.02.06.005--
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Pleural effusion22.05.02.002--
Postoperative wound infection12.02.05.011; 11.01.08.008--Not Available
Pruritus23.03.12.001--
Pyrexia08.05.02.003--
Retinal detachment12.01.04.004; 06.09.03.003--
Rhinorrhoea22.12.03.021--
Seizure17.12.03.001--
Thrombocytopenia01.08.01.002--Not Available
Transplant rejection12.02.05.022; 10.02.03.002--Not Available
Tremor17.01.06.002--
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urinary tract infection20.08.02.001; 11.01.14.004--
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