Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Doxylamine
Drug ID BADD_D02418
Description Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism.
Indications and Usage Used alone as a short-term sleep aid, in combination with other drugs as a night-time cold and allergy relief drug. Also used in combination with Vitamin B6 (pyridoxine) to prevent morning sickness in pregnant women.
Marketing Status approved; vet_approved
ATC Code R06AA09
DrugBank ID DB00366
KEGG ID D07878
MeSH ID D004319
PubChem ID 3162
TTD Drug ID D0Y2LR
NDC Product Code Not Available
UNII 95QB77JKPL
Synonyms Doxylamine
Chemical Information
Molecular Formula C17H22N2O
CAS Registry Number 469-21-6
SMILES CC(C1=CC=CC=C1)(C2=CC=CC=N2)OCCN(C)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acute hepatic failure09.01.03.0010.006036%Not Available
Agitation17.02.05.012; 19.06.02.0010.012073%
Coma17.02.09.0010.006036%Not Available
Completed suicide19.12.01.001; 08.04.01.0100.006036%Not Available
Confusional state19.13.01.001; 17.02.03.0050.006036%
Death08.04.01.0010.015091%
Drug abuse19.07.06.0100.009055%Not Available
Drug dependence19.07.06.0110.012073%Not Available
Drug ineffective08.06.01.0060.039841%Not Available
Dysarthria19.19.03.001; 17.02.08.0010.006036%
Encephalopathy17.13.02.0010.006036%
Flushing23.06.05.003; 08.01.03.025; 24.03.01.0020.006036%
Generalised tonic-clonic seizure17.12.01.0020.006036%Not Available
Hallucination19.10.04.0030.006036%
Hallucination, visual19.10.04.0070.006036%Not Available
Hepatocellular injury09.01.07.0080.006036%Not Available
Leukocytosis01.02.01.0020.006036%
Musculoskeletal pain15.03.04.0070.009055%
Mydriasis17.02.11.003; 06.05.03.0040.009055%Not Available
Nystagmus06.05.02.006; 17.02.02.0060.006036%
Oliguria20.01.03.0040.006036%Not Available
Pyrexia08.05.02.0030.006036%
Rhabdomyolysis15.05.05.0020.024146%
Sedation17.02.04.0050.006036%Not Available
Seizure17.12.03.0010.018109%
Somnolence17.02.04.006; 19.02.05.0030.009055%
Suicide attempt19.12.01.0040.015091%
Tachypnoea22.02.01.0140.006036%Not Available
Torsade de pointes02.03.04.0050.006036%Not Available
Ventricular extrasystoles02.03.04.0070.006036%Not Available
The 1th Page    1 2    Next   Last    Total 2 Pages