| Drug Name |
Alpelisib |
| Drug ID |
BADD_D02500 |
| Description |
Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α [A179203], which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metabolism. Alpelisib was designed to target this enzyme that appears to be mutated at a rate of nearly 30% in human cancers, leading to hyperactivation.[A179209]
There are several isoform-specific PI3K inhibitors that are under clinical development or currently approved, such as [idelalisib] used for chronic lymphocytic leukemia (CLL).[A179209] Approved by the FDA in May 2019, alpelisib is the first approved PI3K inhibitor indicated for the treatment of hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, PIK3CA-mutated, advanced or metastatic breast cancer in combination with [fulvestrant] for postmenopausal women and male patients. To initiate alpelisib therapy, it is required that the presence of a PIK3CA mutation in the tissue and/or liquid biopsy sample collection should be confirmed via FDA-approved diagnostic tests. Alpelisib is marketed under the trade name Piqray and is available as oral tablets. Studies evaluating the therapeutic effectiveness of alpelisib in other cancers, such as ovarian cancer [A179200] and colorectal cancer [A179203], are under ongoing investigations.
Alpelisib was granted FDA approval on 24 May 2019.[L6652] |
| Indications and Usage |
Alpelisib is indicated in combination with fulvestrant to treat postmenopausal women, and men, with advanced or metastatic breast cancer.[Label] This cancer must be hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, and PIK3CA mutated.[Label] The cancer must be detected by an FDA-approved test following progression on or after an endocrine-based regimen.[Label] |
| Marketing Status |
approved; investigational |
| ATC Code |
L01EM03 |
| DrugBank ID |
DB12015
|
| KEGG ID |
D11011
|
| MeSH ID |
C585539
|
| PubChem ID |
56649450
|
| TTD Drug ID |
D0W7HE
|
| NDC Product Code |
0078-0701; 0078-1021; 0078-1028; 0078-1035; 0078-0708; 0078-0715 |
| UNII |
08W5N2C97Q
|
| Synonyms |
Alpelisib | BYL719 | Piqray | NVP-BYL719 |
