Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Telotristat ethyl
Drug ID BADD_D02503
Description Telotristat only approved oral therapy for carcinoid syndrome diarrhea. Telotristat was approved by the FDA in March, 2017 as Xermelo.
Indications and Usage As a serotonin synthesis inhibitor, telotristat etiprate, has the potential to reduce serotonin levels and address the key elements of carcinoid syndrome.
Marketing Status approved; investigational
ATC Code Not Available
DrugBank ID DB12095
KEGG ID D09974
MeSH ID C000621725
PubChem ID 25181577
TTD Drug ID D0RE6T
NDC Product Code 70183-125; 11014-0462; 70720-125
UNII 8G388563M7
Synonyms telotristat ethyl | Xermelo | LX1032
Chemical Information
Molecular Formula C27H26ClF3N6O3
CAS Registry Number 1033805-22-9
SMILES CCOC(=O)C(CC1=CC=C(C=C1)C2=CC(=NC(=N2)N)OC(C3=C(C=C(C=C3)Cl)N4C=CC(=N4)C)C(F)(F) F)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hepatic steatosis09.01.07.003; 14.08.04.005-Not Available
Hypertension24.08.02.001-
Intestinal obstruction07.13.01.002-Not Available
Iron deficiency anaemia14.13.02.001; 01.03.01.002-Not Available
Joint swelling15.01.02.004-Not Available
Leukocytosis01.02.01.002-
Lymphadenopathy01.09.01.002-Not Available
Malaise08.01.01.003-
Metastases to liver16.22.02.001; 09.04.02.004-Not Available
Nausea07.01.07.001-
Neoplasm malignant16.16.01.001-Not Available
Night sweats23.02.03.006; 08.01.03.031-Not Available
Oedema14.05.06.010; 08.01.07.006-Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007-
Palpitations02.11.04.012-
Pancreatitis07.18.01.001-
Pericardial effusion02.06.01.002-
Pleural effusion22.05.02.002-
Proctalgia07.03.02.001-
Productive cough22.02.03.005-
Pruritus23.03.12.001-
Small intestinal obstruction07.13.06.001-
Stress19.06.02.004-Not Available
Tricuspid valve incompetence02.07.05.001-Not Available
Peripheral swelling08.01.03.053; 02.05.04.015-Not Available
General physical health deterioration08.01.03.018-Not Available
Suprapubic pain08.01.08.017-Not Available
Pulmonary mass22.02.07.004-Not Available
Cluster headache17.14.01.003-Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027-
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