| Drug Name |
Oxymetazoline |
| Drug ID |
BADD_D02579 |
| Description |
Oxymetazoline is an imidazole derivative and a potent, direct-acting alpha (α)-adrenergic agonist with affinity to both α1- and α2-adrenoceptors.[A215542] Oxymetazoline is available in various formulations with a wide variety of clinical implications. The topical formulation of the drug is used to treat persistent facial redness in adults.[L15062] As an effective decongestant, oxymetazoline is available in over-the-counter intranasal sprays used to relieve nasal and sinus congestion caused by a wide variety of conditions, such as common cold, hay fever, and upper respiratory allergies.[A215587, L15092] In dentistry, oxymetazoline and tetracaine combination intranasal spray (Kovanaze) is used for regional anesthesia during dental procedures in children and adults.[L15057] In July 2020, the FDA approved the use of an ophthalmic formulation of oxymetazoline (Upneeq) in adults with acquired blepharoptosis, or ptosis, making it the first FDA-approved medical treatment for this medical condition.[L15042, L15067] |
| Indications and Usage |
Oxymetazoline is indicated for the topical treatment of persistent facial erythema associated with rosacea in adults.[L15062]
Ophthalmic oxymetazoline is indicated for the treatment of acquired blepharoptosis in adults.[L15067]
When used in combination with tetracaine intranasally, oxymetazoline is indicated for regional anesthesia when performing a restorative procedure on Teeth 4-13 and A-J in adults and children who weigh 40 kg or more.[L15057]
Oxymetazoline can be found in over-the-counter nasal products as a nasal decongestant.[L15092]
For off-label uses, oxymetazoline has been used during nasal intubation and during ear, nose, and throat surgery to improve visualization of the airway and to minimize post-operative bleeding.[A215542] |
| Marketing Status |
approved; investigational |
| ATC Code |
D11AX27; R01AA05; R01AB07; S01GA04 |
| DrugBank ID |
DB00935
|
| KEGG ID |
D08322
|
| MeSH ID |
D010109
|
| PubChem ID |
4636
|
| TTD Drug ID |
D09EBS
|
| NDC Product Code |
Not Available |
| UNII |
8VLN5B44ZY
|
| Synonyms |
Oxymetazoline | Oxymetazoline Hydrochloride | Hydrochloride, Oxymetazoline |
