Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Phenylbutazone
Drug ID BADD_D02631
Description A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit considerations indicate that this drug should not be employed for this disease. (From AMA Drug Evaluations Annual, 1994, p1822)
Indications and Usage For the treatment of backache and ankylosing spondylitis
Marketing Status approved; vet_approved
ATC Code M01AA01; M02AA01
DrugBank ID DB00812
KEGG ID D00510
MeSH ID D010653
PubChem ID 4781
TTD Drug ID D07VHR
NDC Product Code 51552-1562; 59348-0010; 49452-5285; 60592-909; 51927-1011; 66064-1050
UNII GN5P7K3T8S
Synonyms Phenylbutazone | Diphenylbutazone | Butazolidin | Butadione | Butadion | Butacote | Butapyrazole | Butapirazol | Fenilbutazon
Chemical Information
Molecular Formula C19H20N2O2
CAS Registry Number 50-33-9
SMILES CCCCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain upper07.01.05.003--
Agranulocytosis01.02.03.001--Not Available
Anaemia01.03.02.001--
Angioedema22.04.02.008; 23.04.01.001; 10.01.05.009--Not Available
Aphthous ulcer07.05.06.002--Not Available
Aplastic anaemia01.03.03.002--Not Available
Cardiac failure congestive02.05.01.002--Not Available
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.011--Not Available
Cyanosis23.06.04.005; 02.11.04.004; 24.03.01.007; 22.02.02.007--
Dermatitis23.03.04.002--Not Available
Dermatitis bullous23.03.01.002--
Drug eruption23.03.05.001; 10.01.01.005; 08.01.06.015--Not Available
Dry mouth07.06.01.002--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.11.05.003--
Erythema23.03.06.001--Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
Face oedema23.04.01.004; 08.01.07.003; 10.01.05.002--
Gastric haemorrhage24.07.02.007; 07.12.01.001--
Gastric ulcer07.04.03.002--
Gastritis07.08.02.001--
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Generalised oedema14.05.06.007; 08.01.07.004--
Glossitis07.14.01.001--Not Available
Haematemesis07.12.02.002; 24.07.02.011--Not Available
Haematuria21.10.01.018; 24.07.01.047; 20.02.01.006--
Hepatitis09.01.07.004--Not Available
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Influenza like illness08.01.03.010--
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