Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Hepatic necrosis
ADR ID BADD_A02009
ADR Hierarchy
09      Hepatobiliary disorders
09.01      Hepatic and hepatobiliary disorders
09.01.07      Hepatocellular damage and hepatitis NEC
09.01.07.002      Hepatic necrosis
Description A disorder characterized by a necrotic process occurring in the hepatic parenchyma. [CTCAE]
MedDRA Code 10019692
MeSH ID Not Available
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Acute and subacute necrosis of liver | Hepatic lobule necrosis | Hepatic necrosis | Hepatic necrosis extensive | Hepatitis necrotizing | Liver necrosis | Necrosis hepatocellular | Necrosis liver | Necrosis liver focal | Subacute hepatic necrosis | Hepatitis necrotising
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00480Clarithromycin0.000447%
BADD_D00499Clomipramine--
BADD_D00511Clozapine--
BADD_D00535Crizotinib0.000112%
BADD_D00555Cyproterone acetate--
BADD_D00568Dacarbazine--
BADD_D00580Dapsone0.000550%
BADD_D00611Desflurane--
BADD_D00648Diazepam0.000101%
BADD_D00653Diclofenac0.000064%
BADD_D00686Diphenhydramine0.000134%
BADD_D00695Disulfiram0.003777%
BADD_D00723Doxorubicin0.000280%
BADD_D00749Efavirenz0.007340%
BADD_D00770Enflurane--
BADD_D00809Escitalopram--
BADD_D00810Escitalopram oxalate--
BADD_D00850Etodolac--
BADD_D00858Everolimus0.000382%
BADD_D00908Floxuridine--
BADD_D00912Fluconazole--
BADD_D00913Flucytosine--
BADD_D00929Fluorometholone--
BADD_D00932Fluoxetine--
BADD_D00933Fluoxetine hydrochloride--
BADD_D00943Flutamide--
BADD_D00948Fluvastatin--
BADD_D00949Fluvastatin sodium--
BADD_D00965Fosfomycin--
BADD_D00966Fosfomycin tromethamine--
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ADReCS-Target
ADR Term Drug Name Target