Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Respiratory failure
ADR ID BADD_A03813
ADR Hierarchy
14      Metabolism and nutrition disorders
14.01      Acid-base disorders
14.01.04      Respiratory acidoses
14.01.04.003      Respiratory failure
22      Respiratory, thoracic and mediastinal disorders
22.02      Respiratory disorders NEC
22.02.06      Respiratory failures (excl neonatal)
22.02.06.002      Respiratory failure
Description A disorder characterized by impaired gas exchange by the respiratory system resulting in hypoxia and a decrease in oxygenation of the tissues that may be associated with an increase in arterial levels of carbon dioxide. [CTCAE] Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed) [MeSH]
MedDRA Code 10038695
MeSH ID D012131
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Failure respiratory | Other pulmonary insufficiency, not elsewhere classified | Pulmonary insufficiency following trauma and surgery | Respiration failure | Respiratory failure | Respiratory failure (excl neonatal) | Respiratory insufficiency | Ventilatory failure | Pulmonary failure | Hypercapnic respiratory failure | Restrictive respiratory insufficiency | Respiratory failure aggravated | Hypoxic respiratory failure | End stage lung disease | Respiratory failure type 1 | Respiratory failure type 2 | Hypoxemic respiratory failure | Hypoxaemic respiratory failure | Respiratory Insufficiency | Respiratory Failure | Respiratory Depression | Ventilatory Depression | Depressions, Ventilatory
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00504Clopidogrel0.000246%
BADD_D00511Clozapine0.090492%
BADD_D00514Cocaine--
BADD_D00515Cocaine hydrochloride--
BADD_D00535Crizotinib0.001925%
BADD_D00544Cyclo-upup--
BADD_D00545Cyclobenzaprine0.000056%
BADD_D00549Cyclophosphamide--
BADD_D00551Cyclosporine0.001050%
BADD_D00560Cytarabine0.004410%
BADD_D00564Dabigatran etexilate--
BADD_D00571Dactinomycin0.000112%
BADD_D00577Dantrolene sodium--
BADD_D00580Dapsone0.001833%
BADD_D00581Daptomycin0.000753%
BADD_D00586Darunavir--
BADD_D00593Decitabine0.001287%
BADD_D00596Deferoxamine0.001239%
BADD_D00611Desflurane0.000179%
BADD_D00623Dexamethasone0.004432%
BADD_D00629Dexmedetomidine0.000196%
BADD_D00630Dexmedetomidine hydrochloride--
BADD_D00638Dextromethorphan--
BADD_D00648Diazepam0.000529%
BADD_D00649Diazoxide0.000219%
BADD_D00668Digoxin0.000579%
BADD_D00674Diltiazem0.000143%
BADD_D00686Diphenhydramine0.000739%
BADD_D00697Dobutamine0.000127%
BADD_D00699Docetaxel--
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