Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Chronic kidney disease
ADR ID BADD_A06271
ADR Hierarchy
20      Renal and urinary disorders
20.01      Renal disorders (excl nephropathies)
20.01.03      Renal failure and impairment
20.01.03.017      Chronic kidney disease
Description A disorder characterized by gradual and usually permanent loss of kidney function resulting in renal failure. [CTCAE] The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION. [MeSH]
MedDRA Code 10064848
MeSH ID D007676; D051436
ADR Severity Grade (FAERS) Not Available
ADR Severity Grade (CTCAE)
Synonym
Chronic renal failure | Chronic renal failure worsened | Insidious renal failure | Irreversible renal failure | Kidney failure chronic | Renal failure chronic | Renal failure chronic aggravated | Chronic renal insufficiency | Chronic kidney disease | Preterminal renal insufficiency | Chronic kidney disease stage 1 | Chronic kidney disease stage 2 | Chronic kidney disease stage 3 | Chronic kidney disease stage 4 | Chronic kidney disease stage G3a | Chronic kidney disease stage G3b | Kidney Failure, Chronic | End-Stage Kidney Disease | Disease, End-Stage Kidney | End Stage Kidney Disease | Kidney Disease, End-Stage | Chronic Kidney Failure | End-Stage Renal Disease | Disease, End-Stage Renal | End Stage Renal Disease | Renal Disease, End-Stage | Renal Disease, End Stage | Renal Failure, End-Stage | End-Stage Renal Failure | Renal Failure, End Stage | Renal Failure, Chronic | Chronic Renal Failure | ESRD
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01698Pegloticase--
BADD_D01701Pemetrexed0.000112%
BADD_D01799Ponatinib0.000168%
BADD_D01814Pralatrexate--
BADD_D01824Pravastatin--
BADD_D01834Prednisone0.000085%
BADD_D01895Quinine0.004403%
BADD_D01898Rabeprazole0.001796%
BADD_D01905Raltegravir0.002472%
BADD_D01906Raltegravir potassium--
BADD_D01909Ramipril0.000513%
BADD_D01912Ranibizumab--
BADD_D01915Ranolazine0.000569%
BADD_D01948Riociguat0.000361%
BADD_D01954Rivaroxaban--
BADD_D01961Rofecoxib--
BADD_D01971Rosuvastatin0.000051%
BADD_D01992Saxagliptin--
BADD_D02002Selegiline--
BADD_D02026Simvastatin0.000034%
BADD_D02028Sirolimus0.000469%
BADD_D02029Sitagliptin0.000425%
BADD_D02053Sofosbuvir0.004798%
BADD_D02066Spironolactone0.000091%
BADD_D02073Streptozocin--
BADD_D02100Sunitinib0.003526%
BADD_D02105Tacrolimus0.009802%
BADD_D02107Tafamidis0.006460%
BADD_D02147Telmisartan0.000521%
BADD_D02154Tenofovir0.352849%
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