Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Amphotericin b
Drug ID BADD_D00132
Description Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.
Indications and Usage Used to treat potentially life threatening fungal infections.
Marketing Status Prescription; Discontinued
ATC Code A01AB04; A07AA07; G01AA03; J02AA01
DrugBank ID DB00681
KEGG ID D00203
MeSH ID D000666
PubChem ID 14956
TTD Drug ID D02DWM
NDC Product Code 38779-0191; 63622-0125; 63622-0123; 65044-7183; 51552-0304; 51927-1726; 45932-0008; 55500-0001; 63622-0124; 62991-1173; 62756-233; 39822-1055; 0469-3051
Synonyms Amphotericin B | Amphotericin | Fungizone | Amphotericin B Cholesterol Dispersion | Amphotericin B Colloidal Dispersion | Amphocil
Chemical Information
Molecular Formula C47H73NO17
CAS Registry Number 1397-89-3
SMILES CC1C=CC=CC=CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC(C(CCC(CC(CC(=O)OC(C(C1O)C)C)O)O)O) O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Cell deathMacrophage migration inhibitory factorP14174T39977Not Available
Cell deathD-dopachrome decarboxylaseP30046Not AvailableNot Available
NeurotoxicityTumor necrosis factorP01375T20178Not Available
NeurotoxicityInterleukin-1 alphaP01583T16340Not Available
NeurotoxicityNitric oxide synthase, inducibleQ06518Not AvailableNot Available
NeurotoxicityInterferon gammaP01579T77664Not Available
NeurotoxicityNuclear factor NF-kappa-B p105 subunitP19838T40192Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cardiovascular disorder24.03.02.009; 02.01.01.001--Not Available
Cellulitis23.09.01.001; 11.02.01.001--Not Available
Cerebral infarction24.04.06.002; 17.08.01.0040.000412%Not Available
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.0090.000618%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.0110.000412%Not Available
Chills15.05.03.016; 08.01.09.0010.001649%
Cholestasis09.01.01.001--Not Available
Coagulopathy01.01.02.001--Not Available
Coma17.02.09.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Conjunctivitis11.01.06.012; 06.04.01.002--
Constipation07.02.02.001--
Cough22.02.03.0010.000824%
Cyanosis22.02.02.007; 02.01.02.002; 24.03.01.007--
Cystitis haemorrhagic20.03.02.003--Not Available
Deafness04.02.01.0010.000412%Not Available
Death08.04.01.0010.001129%
Dehydration14.05.05.001--
Depressed level of consciousness17.02.04.002--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Dermatitis bullous23.03.01.002--
Dermatitis exfoliative23.03.07.001; 10.01.01.0040.000412%
Diarrhoea07.02.01.001--
Diarrhoea haemorrhagic07.02.01.002; 24.07.02.004--Not Available
Diplopia17.17.01.005; 06.02.06.002--Not Available
Discomfort08.01.08.003--Not Available
Disseminated intravascular coagulation24.01.01.010; 01.01.02.0020.000161%
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Drug interaction08.06.03.001--Not Available
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