ADReCS

Pharmaceutical Information

Drug Name	Cisplatin
Drug ID	BADD_D00474
Description	Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
Indications and Usage	For the treatment of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer.
Marketing Status	approved
ATC Code	L01XA01
DrugBank ID	DB00515
KEGG ID	D00275
MeSH ID	D002945
PubChem ID	5702198
TTD Drug ID	D0U5HU
NDC Product Code	16729-288; 25021-253; 0143-9505; 68554-0077; 0143-9504; 68001-283; 44567-509; 50711-0001; 44567-510; 63323-103; 0703-5747; 0703-5748; 44567-530; 60505-6277; 68083-163; 44567-511; 49452-2078; 54875-0001; 67184-0010; 68083-162; 70860-206; 49812-0009; 72659-864
UNII	Q20Q21Q62J
Synonyms	Cisplatin \| cis-Diamminedichloroplatinum(II) \| Platinum Diamminodichloride \| Diamminodichloride, Platinum \| cis-Platinum \| cis Platinum \| Dichlorodiammineplatinum \| cis-Diamminedichloroplatinum \| cis Diamminedichloroplatinum \| cis-Dichlorodiammineplatinum(II) \| NSC-119875 \| Platino \| Platinol \| Biocisplatinum \| Platidiam

Chemical Information

Molecular Formula	PtCl2(NH3)2
CAS Registry Number	15663-27-1
SMILES	N.N.Cl[Pt]Cl
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Renal salt-wasting syndrome	20.05.03.021; 14.05.01.011	0.001007%		Not Available
Gallbladder enlargement	09.03.02.005	0.000112%		Not Available
Metastatic squamous cell carcinoma	16.16.01.010	0.000112%		Not Available
Portal venous gas	07.01.06.033	0.000168%		Not Available
Tumour perforation	16.32.03.031	0.000112%		Not Available
Oral cavity fistula	07.11.05.014	0.000112%
Central nervous system necrosis	24.04.06.032; 17.02.10.020	0.000112%
Oesophageal fistula	07.11.05.013	0.000112%
Fistula of small intestine	12.02.03.026; 07.11.05.010	0.000168%
Stress cardiomyopathy	24.04.04.026; 02.04.01.012	0.000168%		Not Available
Neurosensory hypoacusis	17.04.07.007; 04.02.01.015	0.000280%		Not Available
Frontotemporal dementia	19.20.02.008; 17.03.01.007	0.000112%		Not Available
Mastoid effusion	04.05.05.003	0.000437%		Not Available
Exposed bone in jaw	15.02.04.034	0.000302%		Not Available
Bladder outlet obstruction	20.03.01.019	0.000168%		Not Available
Spinal pain	17.10.01.020; 15.02.01.008; 08.01.08.030	0.000168%		Not Available
Ovarian vein thrombosis	24.01.05.012; 21.11.02.019	-	-	Not Available
Dropped head syndrome	15.05.06.002; 17.05.03.015	0.000224%		Not Available
Large intestinal stenosis	07.13.03.004	0.000224%
Ophthalmic vein thrombosis	24.01.05.011; 06.07.02.007	0.000112%		Not Available
Mucosal toxicity	12.03.01.056; 08.01.06.024	0.000168%		Not Available
Adult failure to thrive	19.15.02.009; 14.03.02.020; 08.01.01.014	0.000112%		Not Available
End stage renal disease	20.01.03.019	0.000112%		Not Available
Atypical haemolytic uraemic syndrome	17.02.10.027; 07.11.01.032; 01.06.02.003; 20.01.03.027	0.000168%		Not Available
Brachiocephalic vein thrombosis	24.01.05.013; 12.02.01.032	0.000112%		Not Available
Brief resolved unexplained event	17.02.05.066; 22.11.02.012; 18.04.15.006	0.000112%		Not Available
Carotid artery perforation	24.11.02.003; 17.08.01.068; 12.02.01.033; 08.07.05.008	0.000168%		Not Available
Cerebral venous sinus thrombosis	24.01.04.021; 17.08.03.006	0.000448%		Not Available
Cervix cancer metastatic	21.06.02.008; 16.12.01.005	0.000112%		Not Available
Congestive hepatopathy	02.05.04.018; 09.01.06.027	0.000112%		Not Available

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