Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Clozapine
Drug ID BADD_D00511
Description A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Indications and Usage For use in patients with treatment-resistant schizophrenia.
Marketing Status approved
ATC Code N05AH02
DrugBank ID DB00363
KEGG ID D00283
MeSH ID D003024
PubChem ID 135398737
TTD Drug ID D0Z1RV
NDC Product Code 73377-150; 51079-288; 51079-749; 51407-085; 63629-2359; 0378-3813; 65862-846; 63552-062; 64374-004; 76072-1010; 16729-142; 57664-345; 0378-0973; 53296-0033; 0093-5416; 51079-921; 51079-922; 57664-211; 65862-845; 69809-0127; 55154-3568; 0378-0825; 0378-0860; 12828-0072; 51407-086; 63629-2360; 69809-0126; 67835-0028; 51862-900; 57664-241; 69809-0135; 70518-3391; 0093-5376; 0093-5417; 51862-902; 60687-404; 60687-415; 63629-2362; 0378-3815; 0904-7088; 65015-706; 0093-5419; 51862-901; 60687-426; 0378-0972; 65862-844; 70518-3357; 65862-847; 0904-7089; 63552-063; 16729-141; 0093-5377; 52817-601; 57664-347; 60687-548; 63629-2361; 69809-0130; 0904-7087; 71554-025; 51862-903
UNII J60AR2IKIC
Synonyms Clozapine | Clozaril | Leponex
Chemical Information
Molecular Formula C18H19ClN4
CAS Registry Number 5786-21-0
SMILES CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Petit mal epilepsy17.12.04.001--Not Available
Phaeochromocytoma16.24.02.004; 05.01.04.004--Not Available
Phenylketonuria17.03.07.002; 14.14.04.002; 03.08.04.002; 20.02.01.018; 19.21.06.002--Not Available
Phlebitis24.12.03.004; 12.02.01.002--
Phobia19.06.03.0020.002690%Not Available
Photosensitivity reaction23.03.09.003--
Pica19.09.01.009; 14.03.02.0140.002690%Not Available
Platelet disorder01.08.03.0010.003057%Not Available
Pleural effusion22.05.02.002--
Pleurisy22.05.01.0010.009783%Not Available
Pleuritic pain22.12.01.0070.003669%
Pleurothotonus17.01.03.0090.009171%Not Available
Pneumonia11.01.09.003; 22.07.01.003--Not Available
Pneumonia aspiration22.07.01.015; 11.01.09.019--Not Available
Pneumothorax22.05.02.003--
Poikilocytosis01.07.02.0090.001834%Not Available
Pollakiuria20.02.02.007--
Polycythaemia vera16.21.03.003; 01.13.03.0020.001834%Not Available
Polydipsia14.05.02.001; 05.03.03.0020.011006%Not Available
Polydipsia psychogenic19.24.01.004; 14.05.02.0020.002446%Not Available
Polyserositis08.01.05.0030.005503%Not Available
Polyuria20.02.03.002--Not Available
Posture abnormal15.03.05.029; 17.02.05.0330.004280%Not Available
Pressure of speech19.19.03.0060.001834%Not Available
Priapism21.03.01.005; 24.04.12.0070.009661%Not Available
Prostatic disorder21.04.01.0010.003057%Not Available
Prostatitis21.09.01.001--Not Available
Protrusion tongue17.02.05.037; 07.14.02.002--Not Available
Pruritus23.03.12.001--
Pseudolymphoma01.09.01.016--Not Available
The 15th Page    First    Pre   15 16 17 18 19    Next   Last    Total 32 Pages
ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene