Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nitric oxide
Drug ID BADD_D01574
Description Nitric oxide or Nitrogen monoxide is a chemical compound with chemical formula NO. This gas is an important signaling molecule in the body of mammals including humans and is an extremely important intermediate in the chemical industry. It is also a toxic air pollutant produced by automobile engines and power plants. Nitric oxide (NO) should not be confused with nitrous oxide (N2O), a general anaesthetic, or with nitrogen dioxide (NO2) which is another poisonous air pollutant. The nitric oxide molecule is a free radical, which is relevant to understanding its high reactivity. It reacts with the ozone in air to form nitrogen dioxide, signalled by the appearance of the reddish-brown color.
Indications and Usage For the treatment of term and near-term (>34 weeks) neonates with hypoxic respiratory failure
Marketing Status approved
ATC Code R07AX01
DrugBank ID DB00435
KEGG ID D00074
MeSH ID D009569
PubChem ID 145068
TTD Drug ID D0A5FM
NDC Product Code 64693-002; 83202-8251; 72385-001; 72385-002; 80519-301; 83202-2278; 83202-6645; 83202-2149; 83202-5147; 83202-6658; 83202-7712; 83202-1857; 83202-6487; 83202-6518; 83202-6931; 83202-7715; 83202-6841; 64693-003; 83202-2952
UNII 31C4KY9ESH
Synonyms Nitric Oxide | Oxide, Nitric | Nitrogen Monoxide | Monoxide, Nitrogen | Nitric Oxide, Endothelium-Derived | Endothelium-Derived Nitric Oxide | Nitric Oxide, Endothelium Derived | Endogenous Nitrate Vasodilator | Nitrate Vasodilator, Endogenous | Vasodilator, Endogenous Nitrate | Mononitrogen Monoxide | Monoxide, Mononitrogen
Chemical Information
Molecular Formula NO
CAS Registry Number 10102-43-9
SMILES [N]=O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Intraventricular haemorrhage24.07.04.008; 17.08.01.017-Not Available
Low cardiac output syndrome02.05.01.008-Not Available
Lung disorder22.02.07.001-Not Available
Methaemoglobinaemia01.05.01.002-
Nervous system disorder17.02.10.001--Not Available
Peripheral ischaemia24.04.03.002-
Pleural effusion22.05.02.002-
Pneumothorax22.05.02.003-
Premature baby18.04.02.001-Not Available
Pulmonary haemorrhage22.12.01.009; 24.07.01.016-
Pulmonary hypertension24.08.03.002; 22.06.01.001-
Pulmonary oedema22.01.03.003; 02.05.02.003-
Rebound effect08.06.02.009-Not Available
Renal failure20.01.03.005-Not Available
Respiratory failure22.02.06.002; 14.01.04.003-
Right ventricular failure02.05.03.002-Not Available
Seizure17.12.03.001--
Shock24.06.02.002-Not Available
Thrombocytopenia01.08.01.002--Not Available
Ventricular fibrillation02.03.04.008-
Ventricular tachycardia02.03.04.010-
General physical health deterioration08.01.03.018-Not Available
Neonatal hypoxia22.11.02.002; 18.04.15.002-Not Available
Cardiopulmonary failure02.05.01.004; 22.02.06.004-Not Available
Catheter site haemorrhage24.07.01.003; 12.07.02.002; 08.02.02.002-Not Available
Necrotising colitis07.08.01.013-Not Available
Lymphatic disorder01.09.01.003--Not Available
Periventricular leukomalacia18.04.07.003; 17.13.02.005--Not Available
Cerebral haematoma24.07.04.006; 17.08.01.014-Not Available
Haemorrhage24.07.01.002-Not Available
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ADReCS-Target
Drug Name ADR Term Target
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