Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Phenobarbital
Drug ID BADD_D01752
Description A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Indications and Usage For the treatment of all types of seizures except absence seizures.
Marketing Status approved; investigational
ATC Code N03AA02
DrugBank ID DB01174
KEGG ID D00506
MeSH ID D010634
PubChem ID 4763
TTD Drug ID D0Y7RW
NDC Product Code 75826-142; 13517-626; 13517-628; 13517-758; 0121-0531; 51293-692; 54932-501; 63629-2399; 69367-214; 70752-163; 71205-892; 16571-673; 0143-1455; 0143-1458; 54932-207; 58118-0626; 60687-448; 62135-406; 62135-412; 63629-1033; 63629-2043; 63629-2045; 63629-2400; 70752-157; 70752-165; 70752-168; 71205-848; 72162-1584; 76003-0894; 13517-691; 16571-671; 0143-1500; 43063-953; 51293-693; 60687-671; 62135-405; 62135-410; 63629-1037; 63629-2402; 69367-172; 70518-2405; 70518-2418; 70518-3469; 70518-3470; 70752-164; 71205-851; 71205-891; 0603-1508; 0603-5165; 58118-1110; 64380-166; 70518-0911; 71205-890; 16571-669; 51293-691; 63629-1034; 63629-1038; 71205-845; 71205-846; 0603-5166; 75826-139; 75826-140; 50095-001; 66064-2001; 13517-625; 13517-627; 13517-693; 13517-757; 16571-672; 51293-627; 63629-2047; 63629-2291; 63629-2403; 70518-3471; 70752-167; 0603-5167; 72162-1583; 75826-143; 0904-6575; 13517-107; 13517-111; 13517-692; 13517-694; 17856-0174; 51293-625; 58118-1626; 62135-409; 63629-1035; 63629-1036; 63629-1039; 63629-2046; 63629-2049; 69367-211; 70518-2407; 70752-162; 13517-110; 13517-756; 16571-667; 16571-668; 16571-670; 0143-1495; 51293-694; 63187-895; 63629-2044; 63629-2289; 63629-2401; 63739-192; 63739-294; 69367-213; 71205-847; 71205-850; 0603-5168; 72162-1581; 75826-136; 75826-137; 51927-1015; 16571-675; 51293-628; 62135-407; 62135-411; 63629-1032; 63629-2041; 63629-2042; 63629-2048; 63629-2290; 69367-212; 70752-166; 71205-849; 71205-889; 71205-893; 72162-1582; 38779-0852; 51552-0745; 58624-0520; 59348-0011; 65319-1450; 62135-408; 63629-2404; 70166-536; 70166-537; 70518-2612; 70752-161; 75826-138; 75826-141; 13517-112; 13517-113; 13517-755; 16571-674; 17856-0678; 51293-626
UNII YQE403BP4D
Synonyms Phenobarbital | Phenylbarbital | Phenylethylbarbituric Acid | Acid, Phenylethylbarbituric | Phenemal | Phenobarbitone | Hysteps | Phenobarbital Sodium | Sodium, Phenobarbital | Phenobarbital, Monosodium Salt | Monosodium Salt Phenobarbital | Luminal | Gardenal
Chemical Information
Molecular Formula C12H12N2O3
CAS Registry Number 50-06-6
SMILES CCC1(C(=O)NC(=O)NC1=O)C2=CC=CC=C2
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nausea07.01.07.001--
Necrosis24.04.02.006; 08.03.03.001--Not Available
Nervousness19.06.02.003--Not Available
Nightmare19.02.03.003--Not Available
Nystagmus17.02.02.006; 06.05.02.0060.000325%
Oedema14.05.06.010; 08.01.07.006--Not Available
Osteomalacia14.04.04.001; 20.01.01.002; 15.02.03.001--Not Available
Pain08.01.08.004--
Palpitations02.11.04.012--
Pancreatitis acute07.18.01.0020.000488%Not Available
Petit mal epilepsy17.12.04.0010.000325%Not Available
Phobia19.06.03.002--Not Available
Pruritus23.03.12.001--
Psychomotor hyperactivity19.11.02.003; 17.01.02.011--Not Available
Psychomotor retardation19.15.02.0020.000325%Not Available
Pulmonary oedema22.01.03.003; 02.05.02.0030.000325%
Purpura24.07.06.005; 23.06.01.004; 01.01.04.003--
Pyrexia08.05.02.0030.000975%
Rash23.03.13.001--Not Available
Rash erythematous23.03.13.029--Not Available
Rash macular23.03.13.003--Not Available
Rash maculo-papular23.03.13.004--
Rash morbilliform23.03.13.005--Not Available
Rash vesicular23.03.13.009--Not Available
Renal failure20.01.03.005--Not Available
Respiratory arrest22.02.01.0090.000325%Not Available
Respiratory depression22.02.01.010; 17.02.05.0470.000650%Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.000325%
Sedation17.02.04.0050.000325%Not Available
Seizure17.12.03.0010.002926%
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ADReCS-Target
Drug Name ADR Term Target
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