| Drug Name |
Phytonadione |
| Drug ID |
BADD_D01770 |
| Description |
Vitamin K1, also called phylloquinone or phytonadione, is a fat soluble vitamin.[L33319,L33345] Phylloquinone is a cofactor of the enzyme γ-carboxylase, which modifies and activates precursors to coagulation factors II, VII, IX, and X.[A234264,A234195,A234259] It is indicated in the treatment of coagulation disorders due to faulty formation of coagulation factors II, VII, IX, and X caused by deficiency or interference in the activity of vitamin K.[L33319]
Phylloquinone has been synthesized since at least 1939,[A234384] and was approved by the FDA prior to 1955.[L33389] |
| Indications and Usage |
Oral phylloquinone is indicated to treat prothrombin deficiency caused by coumarin or indanedione derivatives; and hypoprothrombinemia secondary to antibacterial therapy, salicylates, or obstructive jaundice or biliary fistulas with concomitant bile salt administration.[L33345]
Parenteral (intravenous, intramuscular, and subcutaneous) phylloquinone is indicated to treat coagulation disorders due to faulty formation of coagulation factors II, VII, IX, and X caused by vitamin K deficiency or some interference with vitamin K activity.[L33319] These indications include the above indications as well as hypoprothrombinemia secondary to sprue, ulcerative colitis, celiac disease, intestinal resection, pancreatic cystic fibrosis, or regional enteritis; or hypoprothrombinemia caused by interference with vitamin k metabolism.[L33319] |
| Marketing Status |
approved; investigational |
| ATC Code |
B02BA01 |
| DrugBank ID |
DB01022
|
| KEGG ID |
D00148
|
| MeSH ID |
D010837
|
| PubChem ID |
5284607
|
| TTD Drug ID |
D00FSV
|
| NDC Product Code |
0904-6882; 14501-0027; 76329-1240; 42413-0192; 76339-107; 16714-973; 60687-381; 33656-0010; 52221-124; 76055-0006; 0404-9969; 0409-9157; 63238-4300; 52584-405; 70710-1014; 0409-9158; 69238-1051; 49812-0232; 0404-9935; 69097-709; 65571-0028; 52584-046; 69097-708; 14593-912; 70771-1318; 43598-405 |
| UNII |
A034SE7857
|
| Synonyms |
Vitamin K 1 | Phytonadione | Vitamin K1 | Phytomenadione | Phylloquinone | Phyllohydroquinone | Aquamephyton | Konakion |
