Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pralatrexate
Drug ID BADD_D01814
Description Pralatrexate is an antimetabolite for the treatment of relapsed or refractory peripheral T-cell lymphoma. It is more efficiently retained in cancer cells than methotrexate. FDA approved on September 24, 2009.
Indications and Usage Treatment of relapsed or refractory peripheral T-cell lymphoma.
Marketing Status approved; investigational
ATC Code L01BA05
DrugBank ID DB06813
KEGG ID D05589
MeSH ID C418863
PubChem ID 148121
TTD Drug ID D02LWU
NDC Product Code 72893-005; 47848-045; 53183-4020; 48818-001; 65219-550; 72893-003; 68554-0071; 65219-552; 65392-2510
UNII A8Q8I19Q20
Synonyms 10-propargyl-10-deazaaminopterin | pralatrexate
Chemical Information
Molecular Formula C23H23N7O5
CAS Registry Number 146464-95-1
SMILES C#CCC(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Leukopenia01.02.02.001--Not Available
Liver disorder09.01.08.0010.000112%Not Available
Liver function test abnormal13.03.04.030--Not Available
Lymphadenopathy01.09.01.0020.000112%Not Available
Lymphoma16.20.01.001; 01.12.01.0010.000112%Not Available
Lymphopenia01.02.02.0020.000168%Not Available
Mucosal inflammation08.01.06.0020.000504%Not Available
Myalgia15.05.02.0010.000112%
Nausea07.01.07.001--
Neoplasm malignant16.16.01.001--Not Available
Neutropenia01.02.03.0040.000168%Not Available
Night sweats08.01.03.031; 23.02.03.006--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Pain in extremity15.03.04.010--
Pancytopenia01.03.03.0030.000448%Not Available
Pleural effusion22.05.02.0020.000112%
Pruritus23.03.12.001--
Pyrexia08.05.02.0030.000504%
Rash23.03.13.0010.000224%Not Available
Sepsis11.01.11.003--
Skin disorder23.03.03.0070.000112%Not Available
Skin exfoliation23.03.07.0030.000168%Not Available
Skin lesion23.03.03.0100.000112%Not Available
Skin reaction23.03.03.013; 10.01.03.0190.000246%Not Available
Stevens-Johnson syndrome10.01.01.045; 23.03.01.007; 12.03.01.014; 11.07.01.0050.000280%
Stomatitis07.05.06.0050.001813%
Tachycardia02.03.02.007--Not Available
Therapeutic response decreased08.06.01.0160.000112%Not Available
Thrombocytopenia01.08.01.0020.000112%Not Available
Toxic epidermal necrolysis23.03.01.008; 12.03.01.015; 11.07.01.006; 10.01.01.006--
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