ADReCS

Pharmaceutical Information

Drug Name	Prednisone
Drug ID	BADD_D01834
Description	A synthetic anti-inflammatory glucocorticoid derived from [cortisone].[A187463] It is biologically inert and converted to [prednisolone] in the liver.[L10502] Prednisone was granted FDA approval on 21 February 1955.[L10496]
Indications and Usage	Prednisone is indicated as an anti-inflammatory or immunosuppressive drug for allergic, dermatologic, gastrointestinal, hematologic, ophthalmologic, nervous system, renal, respiratory, rheumatologic, infectious, endocrine, or neoplastic conditions as well as in organ transplant.[L10502]
Marketing Status	approved; vet_approved
ATC Code	A07EA03; H02AB07
DrugBank ID	DB00635
KEGG ID	D00473
MeSH ID	D011241
PubChem ID	5865
TTD Drug ID	D0IL7L
NDC Product Code	80425-0068; 82982-041; 0591-5052; 42291-727; 42708-105; 43063-911; 50090-0439; 50090-3361; 51655-242; 53002-0610; 55154-4950; 58118-0173; 59746-175; 60219-1707; 61919-321; 62135-471; 63187-066; 63629-2255; 63629-2263; 0378-0642; 64380-949; 67296-0138; 67296-1194; 67296-1755; 68071-2304; 68071-5242; 70518-0632; 70518-2115; 70518-2138; 71205-729; 71205-755; 71205-818; 0054-4741; 71335-1926; 0591-5443; 71335-2153; 0603-5336; 76420-068; 80425-0069; 82982-042; 10135-777; 10135-779; 50090-3137; 51655-493; 51655-763; 51655-765; 51655-779; 55154-4938; 59746-171; 60760-932; 63187-807; 63629-2254; 63629-2434; 64380-835; 66267-173; 66267-860; 67296-1444; 68071-2661; 68071-4691; 68071-5195; 68788-7372; 68788-7692; 68788-8166; 68788-9551; 70518-2675; 70518-2704; 70518-3540; 70934-880; 70954-060; 71205-741; 71335-2088; 0054-8739; 72162-1169; 72189-275; 0615-8438; 80425-0105; 64958-0002; 43063-968; 50090-6225; 51655-410; 51655-988; 53002-3090; 54348-506; 55154-4946; 55289-330; 55700-208; 60219-1705; 61919-235; 61919-365; 63629-7917; 67296-0140; 0054-0019; 68788-8212; 70954-061; 71205-089; 71335-1780; 71335-2149; 0054-8724; 0054-8740; 0054-9828; 72162-1170; 0615-8307; 0615-8441; 59651-489; 60760-002; 63629-2256; 64380-782; 67296-1183; 0054-0018; 70518-1553; 70518-2916; 70934-095; 70954-057; 71205-460; 71205-797; 71335-2122; 71335-2134; 0603-5337; 71610-721; 0054-9818; 0615-8306; 72189-489; 0615-8439; 80425-0106; 0904-6923; 13672-033; 10135-778; 43063-703; 45865-670; 53002-3252; 59746-172; 60687-145; 60760-255; 60760-790; 61919-108; 63187-085; 63629-2258; 63629-2435; 0378-0641; 68071-2209; 68071-2578; 68071-3143; 68788-6440; 68788-7752; 68788-8267; 70954-059; 71205-537; 71335-1524; 71335-1628; 71335-1736; 71335-1737; 71335-2051; 0603-5335; 0603-5339; 0615-8440; 75987-021; 75987-022; 0591-5442; 13672-032; 42708-115; 50090-3336; 51655-355; 51655-416; 51655-935; 51655-972; 59651-487; 60219-1708; 62135-470; 63187-300; 63187-997; 63629-2260; 63629-2262; 68071-1779; 68788-8116; 0527-2934; 70518-0305; 70518-0306; 70518-1120; 70882-117; 0054-4742; 71335-1516; 71335-1525; 0603-5338; 76420-067; 13672-031; 51552-0028; 10135-774; 42708-136; 50090-6123; 50090-6259; 51655-068; 51655-359; 51655-701; 53002-3091; 53002-3520; 59651-488; 60687-122; 63187-243; 63629-1579; 63629-2261; 0378-0640; 64380-784; 64380-785; 67296-0247; 67296-1065; 67296-1455; 67296-1457; 68071-2696; 68071-5196; 68071-5233; 0527-2933; 70518-1561; 70518-2676; 70518-3138; 71205-403; 71335-0464; 0615-8395; 72789-235; 0904-7127; 42708-167; 50090-3330; 50090-3354; 50090-5816; 51407-356; 51407-360; 51655-726; 55154-4949; 59651-484; 60760-715; 63629-2257; 68071-2781; 68788-8184; 0527-2930; 70518-0307; 70518-2555; 70518-3142; 70934-096; 70954-056; 71205-407; 71335-0623; 0054-4728; 0054-9817; 72162-1171; 75987-020; 10135-776; 60722-1002; 82298-103; 42291-771; 42708-114; 42708-166; 51655-349; 51655-760; 59651-486; 59746-173; 60219-1706; 60760-615; 63187-037; 67296-1083; 67296-1446; 67544-399; 0054-0017; 70518-3537; 70934-291; 0054-3722; 71205-362; 71335-0335; 71335-0508; 71335-2079; 71610-641; 72162-1172; 72189-246; 80425-0193; 38779-0154; 57582-003; 42708-045; 43063-866; 50090-6122; 51407-355; 51407-357; 51655-197; 51655-541; 51655-716; 53002-3250; 55700-203; 55700-209; 60687-134; 61919-326; 63187-020; 63629-1605; 63629-2259; 63629-2264; 63739-588; 64380-783; 67296-1203; 67296-1767; 67296-1886; 68071-2771; 70518-2314; 70518-2703; 70518-3401; 70518-3476; 70518-3539; 70518-3555; 70954-058; 71205-239; 71205-421; 71205-665; 71335-1915; 71335-2069; 71335-2160; 71335-9715; 72189-430; 0615-8391; 76420-069; 49452-6000; 10135-775; 42291-770; 42291-783; 50090-4785; 50090-5814; 50090-6376; 51407-358; 51407-359; 51655-208; 51655-939; 55154-3564; 58118-5442; 59651-485
UNII	VB0R961HZT
Synonyms	Prednisone \| Dehydrocortisone \| delta-Cortisone \| Rectodelt \| Prednison Hexal \| Sterapred \| Ultracorten \| Winpred \| Apo-Prednisone \| Cortan \| Cortancyl \| Panafcort \| Cutason \| Decortin \| Dacortin \| Decortisyl \| Deltasone \| Encortone \| Encorton \| Enkortolon \| Kortancyl \| Liquid Pred \| Meticorten \| Orasone \| Panasol \| Predni Tablinen \| Prednidib \| Predniment \| Prednison Acsis \| Acsis, Prednison \| Pronisone \| Sone \| Prednison Galen

Chemical Information

Molecular Formula	C21H26O5
CAS Registry Number	53-03-2
SMILES	CC12CC(=O)C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Resting tremor	17.01.06.008	0.000009%		Not Available
Drug-induced liver injury	12.03.01.044; 09.01.07.023	0.000076%		Not Available
Substance-induced psychotic disorder	19.03.01.007; 12.03.01.053	0.000113%		Not Available
Peripheral artery thrombosis	24.01.02.010	0.000018%		Not Available
Granulomatosis with polyangiitis	24.12.04.011; 22.01.01.015; 20.05.01.013; 10.02.02.018	0.000022%		Not Available
Intraductal proliferative breast lesion	16.10.01.006; 21.05.01.014	0.000009%		Not Available
Reversible cerebral vasoconstriction syndrome	24.04.06.026; 18.06.01.004; 17.08.02.014	0.000009%		Not Available
Drug reaction with eosinophilia and systemic symptoms	12.03.01.064; 23.03.05.005; 10.01.01.021	0.000090%		Not Available
Autoimmune haemolytic anaemia	01.06.01.004; 10.04.01.005	0.000040%		Not Available
Faeces soft	07.01.03.008	0.000022%		Not Available
Noninfective gingivitis	07.09.13.016	-	-	Not Available
Peripheral venous disease	24.04.02.022	0.000009%		Not Available
Mouth swelling	23.04.01.020; 10.01.05.020; 07.05.04.007	-	-	Not Available
Respiratory symptom	22.12.02.013	-	-	Not Available
Sinus node dysfunction	02.03.03.017	0.000018%
Perforation	08.01.03.058	-	-	Not Available
Stenosis	08.01.03.060	-	-	Not Available
Multiple organ dysfunction syndrome	08.01.03.057	0.000282%
Anal incontinence	17.05.01.021; 07.01.06.029	0.000018%
Frustration tolerance decreased	19.04.02.016	0.000013%		Not Available
Adverse food reaction	08.06.01.025	-	-	Not Available
Abdominal mass	07.01.01.003	-	-	Not Available
Abnormal loss of weight	14.03.02.019	0.000009%		Not Available
Acute myelomonocytic leukaemia	01.10.05.005; 16.01.05.005	0.000009%		Not Available
Adenocarcinoma of colon	16.13.01.010; 07.21.01.008	0.000036%		Not Available
Behcet's syndrome	23.06.02.004; 21.10.03.009; 15.01.01.009; 10.02.02.015; 07.05.06.008; 06.04.05.017; 24.12.04.003	0.000013%		Not Available
Bone cancer	16.29.02.002; 15.09.03.012	-	-	Not Available
Brain neoplasm malignant	17.20.04.002; 16.30.04.002	-	-	Not Available
Breast cancer in situ	21.05.01.015; 16.10.01.007	0.000009%		Not Available
Central nervous system lymphoma	18.04.04.013; 17.02.10.028; 16.20.01.005; 01.12.01.005	0.000018%		Not Available

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