| Drug Name |
Prochlorperazine |
| Drug ID |
BADD_D01848 |
| Description |
Prochlorperazine, also known as compazine, is a piperazine phenothiazine and first-generation antipsychotic drug that is used for the treatment of severe nausea and vomiting, as well as short-term management of psychotic disorders such as generalized non-psychotic anxiety and schizophrenia.[label] It mainly works by depressing the chemoreceptor trigger zone and blocking D2 dopamine receptors in the brain. It was shown to also block histaminergic, cholinergic and noradrenergic receptors.[L6637] Prochlorperazine was first developed in the 1950s [L6643] and was first approved by the FDA in 1956. Although newer antiemetic agents such as 5-HT3 antagonists are more heavily promoted, prochlorperazine is still widely used in nausea and vomiting.[L6640] |
| Indications and Usage |
Indicated for the symptomatic treatment of severe nausea and vomiting.[label]
Indicated for the management of manifestations of psychotic disorders, such as schizophrenia and generalized non-psychotic anxiety. The use of prochlorperazine for the management of generalized non-psychotic anxiety is typically not a first-line therapy and should be limited to doses of less than 20 mg per day or for shorter than 12 weeks.[label,L6634]
Off-label uses include use in emergency settings for adult and pediatric migraines. The American Headache Society recommends the use of prochlorperazine as the first-line medication in this setting. In pediatric migraines, a non-steroidal anti-inflammatory agent is often used in combination with dopamine antagonist.[L6637] |
| Marketing Status |
approved; vet_approved |
| ATC Code |
N05AB04 |
| DrugBank ID |
DB00433
|
| KEGG ID |
D00493
|
| MeSH ID |
D011346
|
| PubChem ID |
4917
|
| TTD Drug ID |
D0B2UZ
|
| NDC Product Code |
63629-8444; 54348-114; 55289-119; 69575-4017; 46204-0007; 54348-989; 0713-0135; 0574-7226 |
| UNII |
YHP6YLT61T
|
| Synonyms |
Prochlorperazine | Prochlorperazine Edisylate Salt | Edisylate Salt, Prochlorperazine | Salt, Prochlorperazine Edisylate | Prochlorperazine Edisylate | Edisylate, Prochlorperazine | Prochlorperazine Maleate | Maleate, Prochlorperazine | Compazine |
