Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sumatriptan
Drug ID BADD_D02098
Description Sumatriptan is a serotonin receptor agonist commonly used to treat migraines and sometimes cluster headaches.[L6793,L6796,L6799,L6805,L6808,L6811] Sumatriptan is the first of the triptans and was made available in Europe in 1991 to treat migraines.[A179761] Sumatriptan was granted FDA approval on 28 December 1992.[L6805]
Indications and Usage A combination sumatriptan and [naproxen] tablet is indicated for the treatment of migraines with or without auras in patients 12 years of age and older.[L6793] Sumatriptan nasal powder, nasal spray, subcutaneous injection, and tablets are indicated to treat migraines with or without auras in adults.[L6796,L6799,L6805,L6808,L6811] One of the subcutaneous formulations of sumatriptan is also indicated to treat cluster headaches in adults[L6805], while the other subcutaneous formulation is not.[L6808]
Marketing Status approved; investigational
ATC Code N02CC01
DrugBank ID DB00669
KEGG ID D00451
MeSH ID D018170
PubChem ID 5358
TTD Drug ID D0Z6UC
NDC Product Code 80425-0258; 52932-0733; 42043-220; 65145-118; 72189-404; 62331-048; 42043-222; 55150-173; 55700-969; 63629-8701; 0173-0737; 55700-918; 70069-804; 0527-1859; 63304-097; 69452-344; 0480-2014; 45802-619; 0173-0736; 0245-0812; 60429-995; 63304-098; 63304-099; 53873-058; 67835-5011; 0173-0479; 0173-0524; 66993-084; 0527-1818; 36000-289; 66993-082; 69452-345; 69452-346; 71921-170; 58437-017; 0143-9638; 0173-0523; 63187-164; 63187-323; 63629-8703; 69097-644; 80425-0318; 50370-0029; 53873-057; 58437-016; 58437-018; 0173-0735; 53002-3562; 66993-083; 80425-0224; 53873-059; 42043-221; 0173-0478; 66993-081; 68071-2825; 0480-2013; 45802-598; 0173-0739
UNII 8R78F6L9VO
Synonyms Sumatriptan | 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide | Sumatriptan Succinate | Succinate, Sumatriptan | GR-43175 | GR 43175 | GR43175 | Imigran
Chemical Information
Molecular Formula C14H21N3O2S
CAS Registry Number 103628-46-2
SMILES CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Musculoskeletal deformity15.10.03.001--
Oral disorder07.05.01.005--Not Available
Skin mass23.07.04.014--Not Available
Brain injury19.07.03.007; 17.11.01.003--Not Available
Application site haematoma12.07.01.031; 08.02.01.031; 24.07.01.024--Not Available
Oropharyngeal discomfort22.12.03.015; 07.05.05.008--Not Available
Oropharyngeal pain22.12.03.016; 07.05.05.0040.000083%
Acute kidney injury20.01.03.016--
Medication overuse headache17.14.01.015; 08.06.02.0150.000111%Not Available
Rheumatic disorder15.03.04.018; 10.02.01.048--Not Available
Reversible cerebral vasoconstriction syndrome24.04.06.026; 18.06.01.004; 17.08.02.0140.000167%Not Available
Sinus node dysfunction02.03.03.017--
Anal incontinence17.05.01.021; 07.01.06.0290.000056%
Liver function test increased13.03.04.031--Not Available
Persistent depressive disorder19.15.01.006--Not Available
Balint's syndrome17.02.03.016; 06.08.03.0220.000083%Not Available
Stress cardiomyopathy24.04.04.026; 02.04.01.0120.000083%Not Available
Autonomic dysreflexia24.08.02.016; 17.05.01.022; 12.01.13.0070.000056%Not Available
Thunderclap headache17.14.01.0180.000056%Not Available
Unmasking of previously unidentified disease08.01.03.0800.000056%Not Available
Central nervous system vasculitis24.12.04.005; 17.08.02.029; 10.02.02.030--Not Available
Giant cell arteritis24.12.02.003; 17.08.02.033; 10.02.02.032; 06.07.02.010--Not Available
Intermenstrual bleeding21.01.01.015--Not Available
Pharyngeal swelling22.04.05.0280.000083%Not Available
Therapy non-responder08.06.01.0630.000122%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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