Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Constipation
ADR ID BADD_A01059
ADR Hierarchy
07      Gastrointestinal disorders
07.02      Gastrointestinal motility and defaecation conditions
07.02.02      Gastrointestinal atonic and hypomotility disorders NEC
07.02.02.001      Constipation
Description A disorder characterized by irregular and infrequent or difficult evacuation of the bowels. [CTCAE] Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections. | Difficult defecation. | Symptom characterized by the passage of stool once a week or less. [MeSH]
MedDRA Code 10010774
MeSH ID D003248
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Constipation | Constipation (excl faecal impaction) | Iatrogenic constipation | Obstipation | Constipation aggravated | Constipation (excl fecal impaction) | Stools absent | Constipation chronic | Opioid induced constipation | Slow transit constipation | Chronic idiopathic constipation | Absent bowel movement | Habitual constipation | Dyschezia | Colonic Inertia
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00680Dimethyl fumarate0.085496%
BADD_D00686Diphenhydramine--
BADD_D00687Diphenhydramine hydrochloride--
BADD_D00693Disopyramide--
BADD_D00694Disopyramide phosphate--
BADD_D00696Divalproex sodium--
BADD_D00699Docetaxel--
BADD_D00702Dolasetron--
BADD_D00703Dolasetron mesylate--
BADD_D00705Domperidone--
BADD_D00706Donepezil--
BADD_D00707Donepezil hydrochloride--
BADD_D00714Dothiepin hydrochloride--
BADD_D00718Doxazosin0.000361%
BADD_D00719Doxazosin mesylate--
BADD_D00720Doxepin--
BADD_D00721Doxepin hydrochloride--
BADD_D00722Doxercalciferol0.018225%
BADD_D00723Doxorubicin0.001791%
BADD_D00724Doxorubicin hydrochloride--
BADD_D00729Dronabinol0.006498%
BADD_D00733Dulaglutide--
BADD_D00734Duloxetine--
BADD_D00735Duloxetine hydrochloride--
BADD_D00736Dutasteride0.000455%
BADD_D00742Eculizumab--
BADD_D00749Efavirenz--
BADD_D00755Eletriptan--
BADD_D00756Eletriptan hydrobromide--
BADD_D00757Eliglustat0.060804%
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