Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Muscular weakness
ADR ID BADD_A02894
ADR Hierarchy
15      Musculoskeletal and connective tissue disorders
15.05      Muscle disorders
15.05.06      Muscle weakness conditions
15.05.06.001      Muscular weakness
17      Nervous system disorders
17.05      Neuromuscular disorders
17.05.03      Neuromuscular disorders NEC
17.05.03.005      Muscular weakness
Description A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be characterized as subacute or chronic, often progressive, and is a manifestation of many muscle and neuromuscular diseases. (From Wyngaarden et al., Cecil Textbook of Medicine, 19th ed, p2251) [MeSH]
MedDRA Code 10028372
MeSH ID D018908
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Hands weakness of | Lower extremities weakness of | Muscle weakness | Muscle weakness NOS | Muscular weakness | Myasthenia | Weakness muscle | Weakness of limbs | Weakness voluntary muscle | Muscle weakness aggravated | Asthenia legs | Weakness of arms | Localised muscle weakness | Localized muscle weakness | Generalised muscle weakness | Generalized muscle weakness | Neuromuscular weakness | Weakness in extremity | Muscle weakness lower limb | Muscle weakness trunk | Muscle weakness upper limb | Descending muscle weakness | Weakness of upper extremities | Neck muscle weakness | Proximal muscle weakness | Dynapenia | Skeletal muscle weakness | Masticatory muscle weakness | Asymmetric muscle weakness of limbs | Asymmetric muscle weakness of lower limbs | Muscle Weakness | Muscle Weaknesses | Weakness, Muscle | Weaknesses, Muscle | Muscular Weakness | Muscular Weaknesses | Weakness, Muscular | Weaknesses, Muscular
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D02492Deflazacort0.000576%
BADD_D02493Selinexor0.000358%
BADD_D02497Avatrombopag0.000503%
BADD_D02504Lorlatinib--
BADD_D02507Deutetrabenazine0.007214%
BADD_D02508Edaravone0.006945%
BADD_D02509Brigatinib0.000772%
BADD_D02510Rucaparib0.003582%
BADD_D02511Siponimod0.006606%
BADD_D02514Etelcalcetide0.013679%
BADD_D02517Enasidenib0.000604%
BADD_D02524Ivosidenib0.000817%
BADD_D02526Larotrectinib0.000112%
BADD_D02533Bempedoic acid0.000073%
BADD_D02535Binimetinib0.000112%
BADD_D02539Calcium0.000783%
BADD_D02540Capmatinib0.000112%
BADD_D02548Darolutamide0.000334%
BADD_D02550Diroximel fumarate0.002580%
BADD_D02553Entrectinib0.000224%
BADD_D02556Ferrous cation0.001882%
BADD_D02558Gadolinium cation (3+)-
BADD_D02562Lasmiditan0.000486%
BADD_D02563Lemborexant0.000444%
BADD_D02569Magnesium0.000294%
BADD_D02580Ozanimod0.008318%
BADD_D02584Ponesimod0.000241%
BADD_D02587Relugolix0.001702%
BADD_D02592Risdiplam0.022062%
BADD_D02594Selumetinib0.000246%
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