Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sertraline
Drug ID BADD_D02010
Description Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Indications and Usage Sertraline is indicated for the management of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD).[L9016] Common off-label uses for sertraline include the prevention of post stroke depression[A187078], generalized anxiety disorder (GAD), fibromyalgia, premature ejaculation, migraine prophylaxis, diabetic neuropathy, and neurocardiogenic syncope.[L5227]
Marketing Status approved
ATC Code N06AB06
DrugBank ID DB01104
KEGG ID D02360
MeSH ID D020280
PubChem ID 68617
TTD Drug ID D0K0TC
NDC Product Code 76282-214; 23155-759; 68180-353; 55700-225; 63187-055; 70518-0153; 70518-1461; 70518-1617; 71335-9714; 0615-7990; 65427-009; 55154-3570; 0615-7991; 76282-212; 0904-6924; 50090-5848; 70518-1040; 23155-757; 70518-2512; 0904-6925; 68180-351; 68180-352; 68071-4400; 63187-212; 68788-7329; 0615-7989; 0904-6926; 55154-3569; 63187-478; 67296-1199; 70934-958; 76282-213; 23155-758; 50090-0989
UNII QUC7NX6WMB
Synonyms Sertraline | Zoloft | Altruline | Lustral | Apo-Sertraline | Apo Sertraline | Aremis | Besitran | Sealdin | Gladem | Novo-Sertraline | Novo Sertraline | ratio-Sertraline | ratio Sertraline | Rhoxal-sertraline | Rhoxal sertraline | Sertraline Hydrochloride | Hydrochloride, Sertraline | Sertraline Hydrochloride (1S-cis)-Isomer | Gen-Sertraline | Gen Sertraline
Chemical Information
Molecular Formula C17H17Cl2N
CAS Registry Number 79617-96-2
SMILES CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Periodic limb movement disorder19.02.05.009; 17.15.04.006; 15.05.03.0340.000047%Not Available
Tachyphrenia19.10.03.010; 17.03.03.0070.000113%Not Available
Excessive eye blinking06.05.01.004; 17.17.02.0100.000032%Not Available
Fine motor delay19.22.01.003; 17.01.02.0190.000013%Not Available
Stress cardiomyopathy24.04.04.026; 02.04.01.0120.000025%Not Available
Tethered cord syndrome20.03.03.007; 17.10.01.0230.000019%Not Available
Right atrial dilatation02.04.02.0320.000032%Not Available
Left atrial dilatation02.04.02.0250.000025%Not Available
Heart valve incompetence02.07.02.0030.000045%Not Available
Skin plaque23.03.03.0440.000013%Not Available
Haemorrhagic hepatic cyst16.06.02.003; 09.01.08.013; 24.07.01.0700.000038%Not Available
Reflux laryngitis22.04.01.0070.000038%Not Available
Facial asymmetry15.10.05.0040.000013%Not Available
Overconfidence19.05.01.0200.000028%Not Available
Gross motor delay19.22.01.004; 17.01.02.0210.000013%Not Available
Subretinal fluid12.01.04.031; 06.09.03.0270.000013%Not Available
Motor developmental delay17.01.02.023; 19.22.01.0050.000032%Not Available
Herbal interaction08.06.03.0050.000089%Not Available
Limb asymmetry15.10.03.0090.000013%
Psychological trauma19.01.02.0170.000019%Not Available
Glucocorticoid deficiency05.01.02.011; 14.11.01.0370.000032%Not Available
Stiff person syndrome10.04.10.017; 17.05.02.018; 15.05.04.0210.000013%Not Available
Neonatal behavioural syndrome22.11.02.007; 18.04.04.010; 17.02.05.058; 15.05.04.0200.000153%Not Available
Hyponatraemic seizure17.12.03.025; 14.05.04.0080.000013%Not Available
Genital paraesthesia17.02.06.032; 21.10.05.0160.000013%Not Available
Autoscopy19.10.05.001; 17.02.03.0150.000019%Not Available
Alveolar bone resorption15.02.03.013; 07.09.05.0100.000013%Not Available
Hypoosmolar state14.05.01.0100.000013%Not Available
Poor feeding infant18.04.06.006; 14.03.02.0220.000070%Not Available
Unmasking of previously unidentified disease08.01.03.0800.000032%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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