Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Fatigue
ADR ID BADD_A01626
ADR Hierarchy
08      General disorders and administration site conditions
08.01      General system disorders NEC
08.01.01      Asthenic conditions
08.01.01.002      Fatigue
Description A disorder characterized by a state of generalized weakness with a pronounced inability to summon sufficient energy to accomplish daily activities. [CTCAE] The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli. [MeSH]
MedDRA Code 10016256
MeSH ID D005221
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Enervation | Exhaustion | Exhaustion due to excessive exertion | Exhaustion due to exposure | Fatigability | Fatigability generalized | Fatigability lumbar | Fatigability of knees | Fatigue | Fatigue extreme | Fatiguability | Lassitude | Loss physical strength | Prostration | TATT | Tired all the time | Tired and heavy | Tired out | Tiredness | Washed-out | Weariness | Worn out | Fatigue aggravated | Depressive weariness | Fatigueability generalised | Chronic fatigue | Fatiguability generalised
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D02507Deutetrabenazine0.020188%
BADD_D02509Brigatinib0.003470%
BADD_D02510Rucaparib0.135444%
BADD_D02511Siponimod0.039229%
BADD_D02515Pexidartinib0.011159%
BADD_D02517Enasidenib0.007253%
BADD_D02524Ivosidenib0.012088%
BADD_D02526Larotrectinib0.001892%
BADD_D02527Abrocitinib--
BADD_D02528Asciminib0.001175%
BADD_D02529Atogepant0.001359%
BADD_D02531Avapritinib0.001690%
BADD_D02532Belumosudil0.000820%
BADD_D02533Bempedoic acid0.000218%
BADD_D02534Berotralstat-
BADD_D02535Binimetinib0.000851%
BADD_D02539Calcium0.002349%
BADD_D02540Capmatinib0.002854%
BADD_D02542Cenobamate0.001731%
BADD_D02543Clascoterone0.000419%
BADD_D02548Darolutamide0.009643%
BADD_D02550Diroximel fumarate0.010247%
BADD_D02551Docusate0.000149%
BADD_D02552Encorafenib0.001556%
BADD_D02554Fedratinib0.001936%
BADD_D02555Fenfluramine--
BADD_D02556Ferrous cation0.003765%
BADD_D02562Lasmiditan0.003623%
BADD_D02564Lofexidine0.002746%
BADD_D02569Magnesium0.001030%
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ADReCS-Target
ADR Term Drug Name Target