Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Ocriplasmin
Drug ID BADD_D01594
Description Ocriplasmin is a recombinant truncated form of human plasmin with a molecular weight of 27.2 kDa produced by recombinant DNA technology in a Pichia pastoris expression system. Ocriplasmin is a protein made up of 249 amino acids and has two peptide chains. Agent for pharmacologic vitreolysis; thrombolytic agent. FDA approved in October 17, 2012.
Indications and Usage Ocriplasmin is a proteolytic enzyme indicated for the treatment for symptomatic vitreomacular adhesion.
Marketing Status approved
ATC Code S01XA22
DrugBank ID DB08888
KEGG ID D09646
MeSH ID C054561
PubChem ID Not Available
TTD Drug ID Not Available
NDC Product Code Not Available
UNII 7V6HE3DM5A
Synonyms microplasmin | ocriplasmin
Chemical Information
Molecular Formula Not Available
CAS Registry Number 1048016-09-6
SMILES Not Available
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cataract06.06.01.001--
Chromatopsia06.02.05.001--Not Available
Conjunctival haemorrhage06.07.01.001; 24.07.05.001--Not Available
Dry eye06.08.02.001--
Eye pain06.08.03.002--
Intraocular pressure increased13.07.04.002--Not Available
Iritis10.02.01.022; 06.04.03.002--Not Available
Lens dislocation12.01.04.019; 06.06.05.004--Not Available
Macular oedema06.04.06.005--Not Available
Night blindness06.02.10.010; 14.12.03.001--
Photophobia17.17.02.006; 06.01.01.004--
Photopsia17.17.01.006; 06.02.06.004--
Pupillary reflex impaired06.05.03.009; 17.02.11.007--Not Available
Retinal degeneration06.09.03.002--Not Available
Retinal oedema24.03.07.006; 06.04.06.007--Not Available
Retinal tear12.01.04.014; 06.09.03.010--
Vision blurred17.17.01.010; 06.02.06.007--
Visual acuity reduced06.02.10.012; 17.17.01.011--
Visual impairment06.02.10.013--Not Available
Vitreous detachment12.01.04.005; 06.09.01.002--Not Available
Vitreous floaters06.09.01.005--
Macular hole06.09.03.009--Not Available
Conjunctival hyperaemia06.04.01.004--Not Available
Ocular discomfort06.08.03.008--Not Available
Anterior chamber cell06.04.10.001--Not Available
Cystoid macular oedema12.02.02.005; 06.04.06.010--Not Available
Metamorphopsia17.17.01.020; 06.02.06.014--Not Available
Intravitreal implant25.11.01.002--Not Available
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